Original Research

Accepted on 17 May 2024

Anti-angiogenic and antioxidant effects of axitinib in human retinal endothelial cells: implications in diabetic retinopathy

in Experimental Pharmacology and Drug Discovery

Francesca Lazzara
Federica Conti
Pradip K. Sasmal
Shanavas Alikunju Alikunju
Settimio Rossi
Filippo Drago
Chiara Bianca Maria Platania
Claudio Bucolo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1415846

Clinical Trial

Accepted on 17 May 2024

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial

in Translational Pharmacology

Yuzhou Gui
Wei Wang
Qingqing Wu
Qichen Ding
Hongjie Qian
Qiubei Lu
Yingjun Zhang
Yulei Zhuang
Li Deng
Yinglin Zuo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1359939

Systematic Review

Accepted on 17 May 2024

Concomitant use of renin-angiotensin system inhibitors augments the efficacy of immune checkpoint inhibitors: A systematic review and metaanalysis

in Pharmacology of Anti-Cancer Drugs

Junjie Yu
Fangang Meng
Wenxia Sui
Junmin Yu
Jinhai Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378577

Original Research

Accepted on 17 May 2024

Implementation of Risk-based Lipid-lowering Therapies in Older (age ≥ 65 years) and Very-old Adults (age ≥ 75 years) with Ischemic Heart Disease in the Greater Salzburg Region

in Drugs Outcomes Research and Policies

Kristen Laura Kopp
Lukas J Motloch
Bernhard Wernly
Alexander E Berezin
Victoria Maringgele
Anna Maria Dieplinger
Uta C Hoppe
Michael Lichtenauer

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1357334

Original Research

Accepted on 17 May 2024

Clinical significance and biological function of interferon regulatory factor 1 in non-small cell lung cancer

in Pharmacology of Anti-Cancer Drugs

Shuhua Tan
Jialin Su
Yuning Li
Xinglong Chen
Jiasi Liu
Yongzhong Luo
Changqie Pan
Lemeng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1413699

Review

Accepted on 17 May 2024

Gut-directed therapy in Parkinson's disease

in Inflammation Pharmacology

Laura Benvenuti
Clelia Di Salvo
Gabriele Bellini
Luisa Seguella
Francesco Rettura
Giuseppe Esposito
Luca Antonioli
Roberto Ceravolo
Carolina Pellegrini
Matteo Fornai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1407925

Original Research

Accepted on 17 May 2024

Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment in schizophrenia: results from the multicenter FACE-SZ cohort

in Pharmacoepidemiology

Nathan Vidal
Paul Roux
Mathieu Urbach
Cristobal Belmonte
Laurent Boyer
Delphine Capdevielle
Julie Clauss-Kobayashi
Thierry D'Amato
Romane Dassing
Caroline Dubertret

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1403093

Editorial

Published on 17 May 2024

Editorial: Anti-inflammatory drug development focusing on immune mediated diseases

in Inflammation Pharmacology

José Fernando Oliveira-Costa
Amit Prasad

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1413141

Systematic Review

Published on 17 May 2024

Efficacy and safety of FLT3 inhibitors in monotherapy of hematological and solid malignancies: a systemic analysis of clinical trials

in Pharmacology of Anti-Cancer Drugs

Yuying Zhao
Xuedi Zhang
Xiaoyan Ding
Ying Wang
Zhenpeng Li
Ronglan Zhao
Hai-En Cheng
Yanli Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1294668

Original Research

Published on 17 May 2024

Benserazide, a cystathionine beta-synthase (CBS) inhibitor, potentially enhances the anticancer effects of paclitaxel via inhibiting the S-sulfhydration of SIRT1 and the HIF1-α/VEGF pathway

in Experimental Pharmacology and Drug Discovery

Wei Zhao
Shasha Feng
Jian Wang
Zhenshuai Zhang
Lu Chen
Li Jiang
Ming Li
Tianxiao Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1404532

103 views

Correction

Published on 17 May 2024

Corrigendum: NmFGF1-regulated glucolipid metabolism and angiogenesis improves functional recovery in a mouse model of diabetic stroke and acts via the AMPK signaling pathway

in Experimental Pharmacology and Drug Discovery

Yeli Zhao
Shasha Ye
Jingjing Lin
Fei Liang
Jun Chen
Jian Hu
Kun Chen
Yani Fang
Xiongjian Chen
Ye Xiong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1392148

Original Research

Published on 17 May 2024

To elucidate the mechanism of “Scrophulariae Radix–Fritillaria” in goiter by integrated metabolomics and serum pharmaco-chemistry

in Experimental Pharmacology and Drug Discovery

Lixin Chen
Wei Liang
Kun Zhang
Zishuo Wang
Wei Cheng
Wenlan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1206718

Original Research

Published on 17 May 2024

Repeated epidural delivery of Shinbaro2: effects on neural recovery, inflammation, and pain modulation in a rat model of lumbar spinal stenosis

in Experimental Pharmacology and Drug Discovery

Jin Young Hong
Changhwan Yeo
Hyun Kim
Junseon Lee
Wan-Jin Jeon
Yoon Jae Lee
In-Hyuk Ha

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1324251

Clinical Trial

Published on 17 May 2024

A single-dose, randomized, open-label, four-period, crossover equivalence trial comparing the clinical similarity of the proposed biosimilar rupatadine fumarate to reference Wystamm® in healthy Chinese subjects

in Drug Metabolism and Transport

Sisi Lin
Yutao Lou
Rui Hao
Yiming Shao
Jin Yu
Lu Fang
Meihua Bao
Wu Yi
Yiwen Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1328142

Original Research

Published on 17 May 2024

LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a

in Gastrointestinal and Hepatic Pharmacology

Devadoss J. Samuvel
John J. Lemasters
C. James Chou
Zhi Zhong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1386238

129 views

Review

Published on 17 May 2024

The structure and function of FUN14 domain-containing protein 1 and its contribution to cardioprotection by mediating mitophagy

in Cardiovascular and Smooth Muscle Pharmacology

Yuhu Lv
Zhengze Yu
Peiwen Zhang
Xiqian Zhang
Huarui Li
Ting Liang
Yanju Guo
Lin Cheng
Fenglin Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1389953

218 views

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Articles

Anti-angiogenic and antioxidant effects of axitinib in human retinal endothelial cells: implications in diabetic retinopathy

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a soluble guanylate cyclase stimulator, HEC95468, in healthy volunteers: a randomized, double-blinded, placebo-controlled phase 1 trial

Concomitant use of renin-angiotensin system inhibitors augments the efficacy of immune checkpoint inhibitors: A systematic review and metaanalysis

Implementation of Risk-based Lipid-lowering Therapies in Older (age ≥ 65 years) and Very-old Adults (age ≥ 75 years) with Ischemic Heart Disease in the Greater Salzburg Region

Clinical significance and biological function of interferon regulatory factor 1 in non-small cell lung cancer

Gut-directed therapy in Parkinson's disease

Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment in schizophrenia: results from the multicenter FACE-SZ cohort

Editorial: Anti-inflammatory drug development focusing on immune mediated diseases

Efficacy and safety of FLT3 inhibitors in monotherapy of hematological and solid malignancies: a systemic analysis of clinical trials

Benserazide, a cystathionine beta-synthase (CBS) inhibitor, potentially enhances the anticancer effects of paclitaxel via inhibiting the S-sulfhydration of SIRT1 and the HIF1-α/VEGF pathway

Corrigendum: NmFGF1-regulated glucolipid metabolism and angiogenesis improves functional recovery in a mouse model of diabetic stroke and acts via the AMPK signaling pathway

To elucidate the mechanism of “Scrophulariae Radix–Fritillaria” in goiter by integrated metabolomics and serum pharmaco-chemistry

Repeated epidural delivery of Shinbaro2: effects on neural recovery, inflammation, and pain modulation in a rat model of lumbar spinal stenosis

A single-dose, randomized, open-label, four-period, crossover equivalence trial comparing the clinical similarity of the proposed biosimilar rupatadine fumarate to reference Wystamm® in healthy Chinese subjects

LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a

The structure and function of FUN14 domain-containing protein 1 and its contribution to cardioprotection by mediating mitophagy